Ketamine Research

The below are selected research papers supporting the use of ketamine. Feel free to discuss any questions about these with Dr. MacDonald.



A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression
Filippo Drago-Filippo Caraci – F1000 – Post-publication peer review of the biomedical literature – 2017

Acute Antidepressant Effects Of Intramuscular Versus Intravenous Ketamine
Harihar Chilukuri-Narasimhapothula Reddy-Rammohan Pathapati-Arkalgudnagesha Manu-Sharada Jollu-Ahammedbasha Shaik – Indian Journal of Psychological Medicine – 2014

Antidepressant, Mood Stabilizing And Procognitive Effects Of Very Low Dose Sublingual Ketamine In Refractory Unipolar And Bipolar Depression
Diogo Lara-Luisa Bisol-Luciano Munari – The International Journal of Neuropsychopharmacology – 2013

Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder Adriana Feder-Michael Parides-James Murrough-Andrew Perez-Julia Morgan-Shireen Saxena-Katherine Kirkwood-Marije Rot-Kyle Lapidus-Le-Ben Wan-Dan Iosifescu-Dennis Charney – JAMA Psychiatry – 2014

Evidence that Subanesthetic Doses of Ketamine Cause Sustained Disruptions of NMDA and AMPA-Mediated Frontoparietal Connectivity in Humans
Suresh Muthukumaraswamy-Alexander Shaw-Laura Jackson-Judith Hall-Rosalyn Moran-Neeraj Saxena – The Journal of Neuroscience – 2015

Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam-Controlled Randomized Clinical Trial
Michael Grunebaum-Hanga Galfalvy-Tse-Hwei Choo-John Keilp-Vivek Moitra-Michelle Parris-Julia Marver-Ainsley Burke-Matthew Milak-M. Sublette-Maria Oquendo-J. Mann – American Journal of Psychiatry – 2018

Ketamine Treatment For Depression: Opportunities For Clinical Innovation And Ethical Foresight
Ilina Singh-Celia Morgan-Valerie Curran-David Nutt-Anne Schlag-Rupert Mcshane – The Lancet Psychiatry – 2017

Long-Term Maintenance With Intramuscular Ketamine for Treatment-Resistant Bipolar II Depression
Cristina Cusin-George Hilton-Andrew Nierenberg-Maurizio Fava – American Journal of Psychiatry – 2012

Replication of Ketamine’s Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial
Carlos Zarate-Nancy Brutsche-Lobna Ibrahim-Jose Franco-Chaves-Nancy Diazgranados-Anibal Cravchik-Jessica Selter-Craig Marquardt-Victoria Liberty-David Luckenbaugh – Biological Psychiatry – 2012

Safety And Efficacy Of Maintenance Ketamine Treatment In Patients With Treatment-refractory Generalised Anxiety And Social Anxiety Disorders
Paul Glue-Shona Neehoff-Natalie Medlicott-Andrew Gray-Guy Kibby-Neil Mcnaughton – Journal of Psychopharmacology – 2018

Side-effects Associated With Ketamine Use In Depression: A Systematic Review
Brooke Short-Joanna Fong-Veronica Galvez-William Shelker-Colleen Loo – The Lancet Psychiatry – 2018

Synaptic Potentiation Is Critical for Rapid Antidepressant Response to Ketamine in Treatment-Resistant Major Depression
Brian Cornwell-Giacomo Salvadore-Maura Furey-Craig Marquardt-Nancy Brutsche-Christian Grillon-Carlos Zarate – Biological Psychiatry – 2012

What Is The Mechanism Of Ketamine’s Rapid-onset Antidepressant Effect? A Concise Overview Of The Surprisingly Large Number Of Possibilities
Strasburger-P. Bhimani-J. Kaabe-J. Krysiak-D. Nanchanatt-T. Nguyen-K. Pough-T. Prince-N. Ramsey-K. Savsani-L. Scandlen-M. Cavaretta-R. Raffa – Journal of Clinical Pharmacy and Therapeutics – 2017